Long noncoding RNA HOXA-AS2 promotes non-small cell lung cancer progression by regulating miR-520a-3p
Identifieur interne : 000680 ( Main/Exploration ); précédent : 000679; suivant : 000681Long noncoding RNA HOXA-AS2 promotes non-small cell lung cancer progression by regulating miR-520a-3p
Auteurs : Yunpeng Liu [République populaire de Chine] ; Xingyu Lin [République populaire de Chine] ; Shiyao Zhou [République populaire de Chine] ; Peng Zhang [République populaire de Chine] ; Guoguang Shao [République populaire de Chine] ; Zhiguang Yang [République populaire de Chine]Source :
- Bioscience Reports [ 0144-8463 ] ; 2019.
Abstract
Url:
DOI: 10.1042/BSR20190283
PubMed: 31064819
PubMed Central: 6542977
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Long noncoding RNA HOXA-AS2 promotes non-small cell lung cancer progression by regulating miR-520a-3p</title><author><name sortKey="Liu, Yunpeng" sort="Liu, Yunpeng" uniqKey="Liu Y" first="Yunpeng" last="Liu">Yunpeng Liu</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021</wicri:regionArea><wicri:noRegion>Jilin 130021</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Xingyu" sort="Lin, Xingyu" uniqKey="Lin X" first="Xingyu" last="Lin">Xingyu Lin</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021</wicri:regionArea><wicri:noRegion>Jilin 130021</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Shiyao" sort="Zhou, Shiyao" uniqKey="Zhou S" first="Shiyao" last="Zhou">Shiyao Zhou</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Anaesthesia, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Anaesthesia, The First Hospital of Jilin University, Changchun, Jilin 130021</wicri:regionArea><wicri:noRegion>Jilin 130021</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Peng" sort="Zhang, Peng" uniqKey="Zhang P" first="Peng" last="Zhang">Peng Zhang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021</wicri:regionArea><wicri:noRegion>Jilin 130021</wicri:noRegion></affiliation></author><author><name sortKey="Shao, Guoguang" sort="Shao, Guoguang" uniqKey="Shao G" first="Guoguang" last="Shao">Guoguang Shao</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021</wicri:regionArea><wicri:noRegion>Jilin 130021</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Zhiguang" sort="Yang, Zhiguang" uniqKey="Yang Z" first="Zhiguang" last="Yang">Zhiguang Yang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021</wicri:regionArea><wicri:noRegion>Jilin 130021</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31064819</idno><idno type="pmc">6542977</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542977</idno><idno type="RBID">PMC:6542977</idno><idno type="doi">10.1042/BSR20190283</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000434</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000434</idno><idno type="wicri:Area/Pmc/Curation">000434</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000434</idno><idno type="wicri:Area/Pmc/Checkpoint">000628</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000628</idno><idno type="wicri:Area/Ncbi/Merge">000601</idno><idno type="wicri:Area/Ncbi/Curation">000601</idno><idno type="wicri:Area/Ncbi/Checkpoint">000601</idno><idno type="wicri:doubleKey">0144-8463:2019:Liu Y:long:noncoding:rna</idno><idno type="wicri:Area/Main/Merge">000680</idno><idno type="wicri:Area/Main/Curation">000680</idno><idno type="wicri:Area/Main/Exploration">000680</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Long noncoding RNA HOXA-AS2 promotes non-small cell lung cancer progression by regulating miR-520a-3p</title><author><name sortKey="Liu, Yunpeng" sort="Liu, Yunpeng" uniqKey="Liu Y" first="Yunpeng" last="Liu">Yunpeng Liu</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021</wicri:regionArea><wicri:noRegion>Jilin 130021</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Xingyu" sort="Lin, Xingyu" uniqKey="Lin X" first="Xingyu" last="Lin">Xingyu Lin</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021</wicri:regionArea><wicri:noRegion>Jilin 130021</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Shiyao" sort="Zhou, Shiyao" uniqKey="Zhou S" first="Shiyao" last="Zhou">Shiyao Zhou</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Anaesthesia, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Anaesthesia, The First Hospital of Jilin University, Changchun, Jilin 130021</wicri:regionArea><wicri:noRegion>Jilin 130021</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Peng" sort="Zhang, Peng" uniqKey="Zhang P" first="Peng" last="Zhang">Peng Zhang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021</wicri:regionArea><wicri:noRegion>Jilin 130021</wicri:noRegion></affiliation></author><author><name sortKey="Shao, Guoguang" sort="Shao, Guoguang" uniqKey="Shao G" first="Guoguang" last="Shao">Guoguang Shao</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021</wicri:regionArea><wicri:noRegion>Jilin 130021</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Zhiguang" sort="Yang, Zhiguang" uniqKey="Yang Z" first="Zhiguang" last="Yang">Zhiguang Yang</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021</wicri:regionArea><wicri:noRegion>Jilin 130021</wicri:noRegion></affiliation></author></analytic><series><title level="j">Bioscience Reports</title><idno type="ISSN">0144-8463</idno><idno type="eISSN">1573-4935</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold><italic>Background:</italic></bold> The HOXA cluster antisense RNA 2 (HOXA-AS2) has recently been discovered to be involved in carcinogenesis in multiple cancers. However, the role and underlying mechanism of HOXA-AS2 in non-small cell lung cancer (NSCLC) yet need to be unraveled. <bold><italic>Methods:</italic></bold> HOXA-AS2 expression in NSCLC tissues and cell lines was detected using quantitative real-time PCR (qRT-PCR). Furthermore, the effects of HOXA-AS2 on NSCLC cell proliferation, apoptosis, migration, and invasion were assessed by MTS, flow cytometry, wound healing and transwell invasion assays, respectively. Starbase2.0 predicted and luciferase reporter and RNA immunoprecipitation (RIP) assays were used to validate the association of HOXA-AS2 and miR-520a-3p in NSCLC cells. <bold><italic>Results:</italic></bold> Our results revealed that HOXA-AS2 in NSCLC tissues were up-regulated and cell lines, and were associated with poor prognosis and overall survival. Further functional assays demonstrated that HOXA-AS2 knockdown significantly inhibited NSCLC cell proliferation, induced cell apoptosis and suppressed migration and invasion. Starbase2.0 predicted that HOXA-AS2 sponge miR-520a-3p at 3′-UTR, which was confirmed using luciferase reporter and RIP assays. miR-520a-3p expression was inversely correlated with HOXA-AS2 expression in NSCLC tissues. In addition, miR-520a-3p inhibitor attenuated the inhibitory effect of HOXD-AS2-depletion on cell proliferation, migration and invasion of NSCLC cells. Moreover, HOXA-AS2 could regulate HOXD8 and MAP3K2 expression, two known targets of miR-520a-3p in NSCLC. <bold><italic>Conclusion:</italic></bold> These findings implied that HOXA-AS2 promoted NSCLC progression by regulating miR-520a-3p, suggesting that HOXA-AS2 could serve as a therapeutic target for NSCLC.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Torre, L A" uniqKey="Torre L">L.A. Torre</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F. Bray</name></author><author><name sortKey="Siegel, R L" uniqKey="Siegel R">R.L. 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Li</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name></author><author><name sortKey="Hou, W" uniqKey="Hou W">W. Hou</name></author><author><name sortKey="Wang, R" uniqKey="Wang R">R. Wang</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lv, X" uniqKey="Lv X">X. Lv</name></author><author><name sortKey="Li, C Y" uniqKey="Li C">C.Y. Li</name></author><author><name sortKey="Han, P" uniqKey="Han P">P. Han</name></author><author><name sortKey="Xu, X Y" uniqKey="Xu X">X.Y. Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qu, J" uniqKey="Qu J">J. Qu</name></author><author><name sortKey="Li, M" uniqKey="Li M">M. Li</name></author><author><name sortKey="Zhong, W" uniqKey="Zhong W">W. Zhong</name></author><author><name sortKey="Hu, C" uniqKey="Hu C">C. Hu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Yunpeng" sort="Liu, Yunpeng" uniqKey="Liu Y" first="Yunpeng" last="Liu">Yunpeng Liu</name></noRegion><name sortKey="Lin, Xingyu" sort="Lin, Xingyu" uniqKey="Lin X" first="Xingyu" last="Lin">Xingyu Lin</name><name sortKey="Shao, Guoguang" sort="Shao, Guoguang" uniqKey="Shao G" first="Guoguang" last="Shao">Guoguang Shao</name><name sortKey="Yang, Zhiguang" sort="Yang, Zhiguang" uniqKey="Yang Z" first="Zhiguang" last="Yang">Zhiguang Yang</name><name sortKey="Zhang, Peng" sort="Zhang, Peng" uniqKey="Zhang P" first="Peng" last="Zhang">Peng Zhang</name><name sortKey="Zhou, Shiyao" sort="Zhou, Shiyao" uniqKey="Zhou S" first="Shiyao" last="Zhou">Shiyao Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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